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Harms of dependence, withdrawal or discontinuation syndrome

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Review of the evidence on harms associated with dependence, and the short term discontinuation and longer term withdrawal symptoms from prescribed medicines.

This report gives a systematic review of the quantitative literature published in the last 10 years reporting harms from dependence, discontinuation or withdrawal related to the following medicines; benzodiazepines, Z drugs, GABA-ergic medication, opioid pain medications, antidepressants.